Metabolism, Medicine, and Meaning: Rethinking the Fat Jab

The headlines are loud.
The promises are shiny.
Lose weight without eating less.
Reprogram your metabolism.
Inject once a week. Watch the scale drop.

But Bloggyness raises an eyebrow.
Because the real question isn’t “yes or no.”
It’s: What are we being asked to say yes or no to?

The newest contender is RES-010, a weight-loss injection currently in human trials.
Unlike Ozempic or Mounjaro, which suppress appetite, RES-010 claims to:

• Reprogram how cells handle fat and energy
• Boost mitochondrial activity (the “batteries” of cells)
• Convert white fat (storage) into brown fat (burning)
• Target a molecule called miR-22, described as a “master controller” of fat metabolism

In mice, it led to 12% more weight loss without changing food intake.
And the weight didn’t bounce back when the jab stopped.

Sounds revolutionary.
But the study hasn’t been peer-reviewed.
And the mechanism is still speculative, according to independent experts.

Used with care, weight-loss jabs can support:

• Metabolic health: Especially for those with insulin resistance or type 2 diabetes
• Mobility and joint relief: When weight affects movement
• Mental health: For those whose body image or chronic conditions impact wellbeing
• Access and equity: When lifestyle changes aren’t enough or aren’t possible

They can offer scaffolding.
Not shortcuts.
Not shame.

Left unchecked, weight-loss jabs can:

• Reinforce fatphobia: Framing fatness as failure
• Flatten complexity: Ignoring trauma, poverty, neurodivergence, and systemic barriers
• Erase consent: Deepfakes and voice clones are one thing, but what about bodily autonomy?
• Displace nuance: When “health” becomes a number, not a relationship
• Centralise power: Who gets access? Who profits? Who decides what’s “worth treating”?

And let’s be honest:
The backlog of diet culture is real.
We’ve been taught to chase thinness like it’s salvation.
Even when it costs us softness, joy, and self-trust.

• What’s my relationship with my body right now?
• What do I want from this tool: relief, control, possibility, peace?
• What stories have I inherited about weight, worth, and wellness?
• What would support look like without shame?
• What does care mean in my context, not theirs?

Because the fat jab isn’t just a medical intervention.
It’s a cultural mirror.
And we deserve to look into it gently.

• “I can explore options without abandoning my values.”
• “I’m allowed to want change and still honour my body.”
• “Health is not a competition.”
• “Support should feel like support, not surveillance.”
• “My worth is not measured in kilograms.”

The fat jab isn’t good or bad.
It’s a tool.
And tools need context, consent, and care.

You’re allowed to say yes.
You’re allowed to say no.
You’re allowed to say, “not yet,” “not this,” or “not like that.”

Because the real question isn’t “Should I take the jab?”
It’s: What kind of relationship do I want with my body, and what kind of support honours that?

Explore more with us:

• Browse Spiralmore collections
• Read our Informal Blog for relaxed insights
• Discover Deconvolution and see what’s happening
• Visit Gwenin for a curated selection of frameworks

Relentless. Results-driven. Remote-ready.

I manage multiple live websites, numerous publications, and patents – delivering research, strategy, and commercialisation expertise.